Essential System 4: Detoxification

The next issue is proper detoxification. The liver and gallbladder play an important role in clearing excess hormones from the body. Defects in hormone detox can cause hormones to be only partially metabolized. Partially metabolized hormones compete for receptor sites with active hormones, but when they bind to the receptors, they don’t have the same effect, so they actually block the receptors from the active hormones, and that ends up throwing off proper negative feedback, which is the way that hormones are regulated in the body, and the end result is you get symptoms of hormone imbalance but relatively normal labs or a patient that’s extremely sensitive to any drugs or supplements. 

There are some genetic mutations that predispose people to that, but those mutations generally won’t be activated epigenetically unless there’s some kind of issue here with impaired detox pathways. 

Of course, the key here is to make sure those pathways are functioning well and to reduce the toxic burden that we’re exposed to. We’re exposed to toxins in food, of course, with the standard American diet (SAD), the flour, the seed oils, the excess sugar, the chemicals, preservatives, and things that are increasingly used in processed and industrially refined foods, but there are also environmental toxins like BPA and phthalates and the many other chemical agents that are introduced into our environment every year with very little regulation or concern for safety.

So using natural products, shampoos, soaps, natural home cleaning products, washing powder etc – all of this, can help reduce the toxic burden and give our detox pathways a little bit of a break. There are a lot of things that we can do to improve detox capacity, like improving our methylation status and improving our glutathione levels.

Oestrogen is the primary female sex hormone that is responsible for the development and regulation of the female sexual and reproductive system, but it is also an important hormone for men. Oestrogen plays an important role in bone metabolism and protects the cardiovascular system in both men and women. Very low oestrogen levels can lead to weight gain, low libido, muscle weakening, depression, cardiovascular disease, osteoporosis and fatigue. In women, low oestrogen levels can also cause hot flashes, breast tenderness, mood swings, and irregular or absent periods. 

Today we are finding that the majority of people have very high oestrogen levels, referred to as oestrogen dominance. High oestrogen levels can have very negative health consequences. Oestrogen dominance plays a big role in conditions associated with hormone imbalance such as Endometriosis, Fibroids, Polycystic Ovarian Syndrome (PCOS), and Premenstrual Syndrome (PMS). In men, high oestrogen levels can cause the growth of breast tissue (gynecomastia), enlarged prostate, and erectile dysfunction. High oestrogen levels also increase the risk for hormone-sensitive cancers in men and women. Our body’s ability to detoxify all this excess oestrogen is influenced by our DNA, diet, gut health, exercise, liver health, and more. There are also very advanced nutraceutical supplements that support oestrogen detoxification pathways. A healthy lifestyle and the correct supplementation can prevent oestrogen dominance and all the dangers associated with it. 

Frequently Asked Questions

Synthetic hormones - Oral contraceptives contain synthetic hormones which contribute to oestrogen dominance. A lifetime of exposure to these synthetic hormones disrupts hormone balance. Using synthetic hormone replacement therapy (HRT) for menopause significantly raises oestrogen levels and carries risks, especially when oestrogen detoxification is poor. Fertility treatments can also lead to excess oestrogen levels. 

Xenoestrogens - We are exposed to many chemicals in our environment which have estrogenic effects and contributes to oestrogen dominance. We are exposed to xenoestrogens such as BPA and phthalates which are found in plastics (food packaging, water bottles etc.). Many herbicides and pesticides have estrogenic effects and are classified as xenoestrogens. Common preservatives like parabens also have estrogenic activity. 

DNA - There are several common genetic mutations that affect oestrogen metabolism and detoxification pathways. Mutations on one or several of these genes can result in more harmful oestrogen metabolites being formed and/or reduce our ability to detoxify oestrogen metabolites. Genetic testing can identify these genetic mutations and oestrogen metabolism and detoxification pathways can then be modified and supported by nutraceutical supplementation, diet and lifestyle. 

Obesity - Fat cells produce oestrogen, and abdominal obesity can significantly increase oestrogen levels. High oestrogen levels cause more accumulation of belly fat (visceral fat), which can become a vicious cycle.  

Poor gut health - Chronic constipation prevents oestrogen metabolites from being eliminated, and they are reabsorbed into the body, contributing to oestrogen dominance. Unbalanced gut bacteria can also result in more oestrogen metabolites being reabsorbed instead of being excreted.  

Rapid weight loss - A lot of oestrogen is released from fat cells during rapid weight loss. It is important to support oestrogen detoxification during weight loss to prevent oestrogen dominance. 

  • Breast cancer 
  • Anxiety 
  • Endometriosis 
  • Poor sleep 
  • Fibroids 
  • Fatigue 
  • Polycystic Ovarian Syndrome 
  • Decreased sex drive 
  • PMS 
  • Brain fog 
  • Fibrocystic Breast Disease 
  • Poor memory 
  • Weight gain, especially abdominal fat 
  • Hormonal pigmentation (Melasma) 
  • Hair loss 
  • Cellulite 
  • Water retention and bloating 
  • Acne 
  • Irregular or abnormal menstrual cycles 
  • Male infertility 
  • Breast tenderness 
  • Erectile Dysfunction 
  • Headaches 
  • Gynecomastia 
  • Mood swings 
  • Enlarged prostate 
  • Depression 

The biggest risk associated with high oestrogen levels is the increased risk for oestrogen sensitive cancers such as breast, endometrial, ovarian, and prostate cancer. In a world of oestrogen dominance, it is vital to support oestrogen detoxification pathways to lower the risk for these cancers. There is also an increased risk of blood clots and strokes, high blood pressure, low thyroid function, and significant weight gain. Certain autoimmune conditions have also been linked to high oestrogen levels

Sharon Izak Elaine ) WhatsApp
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